Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

Top-Down Proteomics at ASMS2020

An exciting ASMS meeting is upon us and we have compiled a list of all the great presentations and workshops at the ASMS Reboot 2020.

Don’t miss these LIVE events

  • Workshop – Top Down Proteomics and Top Down Mass Spectrometry: Adoption and Expanding Applications  Wednesday June 3 at 12:00-1:30 CDT
  • Ying Ge, Biemann Medal Lecture on her work on high-resolution top-down proteomics and applications to cardiac diseases. Wednesday June 3 at 2:00pm – 3:00pm CDT

Click  here to download the TDP at ASMS2020.

A New Classification System for Proteoform Identifications

Consortium for Top-Down Proteomics Publishes Standard Notation for Proteoforms

February 8, 2018 — The Consortium for Top-Down Proteomics has published the first standard notation, called ProForma, for writing the sequences of fully characterized proteoforms.  ProForma allows researchers to readily communicate and share proteoform information, and the notation is the unambiguous, human readable, and can easily be parsed and written by bioinformatic tools.  This should help simplify storage and comparisons, and increase the utilization of proteoform information, leading to new discoveries.

  • ProForma: a Standard Proteoform Notation
    Richard D. LeDuc, Veit Schwämmle, Michael R. Shortreed, Anthony J. Cesnik, Stefan K. Solntsev, Jared B. Shaw, Maria J. Martin, Juan A. Vizcaíno, Emanuele Alpi, Paul Danis, Neil L. Kelleher, Lloyd M. Smith, Ying Ge, Jeffrey N. Agar, Julia Chamot-Rooke, Joseph Loo, Ljiljana Paša-Tolić, and Yury O. Tsybin, Journal of Proteome Research, published online February 5, 2018.

Why Should We Weigh Every Protein in the Human Body?

This interview with Neil Kelleher, Consortium President, explains the importance of Top-Down Proteomics for understanding biology and accelerating drug discovery efforts.


The Consortium for Top-Down Proteomics to Present Monoclonal Antibodies Study at ASMS 2017

Preliminary results from 25-laboratory study demonstrate the capabilities of top-down mass spectrometry for detailing monoclonal antibody structure and modifications. The presentation is Monday, June 5 at the Top-Down Proteomics Workshop at the ASMS Conference in Indianapolis, IN

CAMBRIDGE, MA–(Marketwired – May 31, 2017) – The Consortium for Top-Down Proteomics will present the preliminary results from their inter-laboratory study for characterizing monoclonal antibodies (mAbs) by top-down mass spectrometry techniques on June 5, 2017 at the upcoming American Society for Mass Spectrometry Annual Conference. With the continuing growth in the development and adoption of mAbs for a wide range of therapeutic uses, there is increasing demand for higher quality characterization of these complex species. This study is assessing the state of the art for providing critical information on these important materials. Read more