• GeCTDPSlide-small
  • BerndWollscheid
  • HeroSlideCTDP
  • HeroSlideHeeren
  • Lingjun Li
  • TopDownCoon
  • Wang
  • MayoHero
  • DorresteinHeroSlide
  • Prism
  • Julia Chamot-Rooke
  • AgarVignette
  • proteoform
  • Ron Hendrickson
  • Yury Tsybin
  • Sanibel Group Picture
  • HeroSlideScheyTopDown
  • HeroSlideItalianTopDown
  • Ljiljana Top Down
  • Soleil
  • Heien
  • University of Wisconsin, Madison
  • ETH Zurich (Swiss Federal Institute of Technology, Zurich)
  • Consortium for Top Down Proteomics
  • FOM Amolf, Netherlands and Protea Biosciences
  • University of Wisconsin, Madison
  • University of Wisconsin, Madison, WI and University of Pennsylvania, Philadelphia, PA
  • Newomics, Inc., Emeryville, CA
  • Mayo Clinic, Rochester, MN
  • University of California, San Diego
  • Proteoforms: Illuminating the True Actors in Biology
  • Structural and Proteomics Mass Spectrometry Unit, Institut Pasteur (Paris)
  • Mass Spectrometry and Neurodegenerative Disease Research, Northeastern University
  • Proteoform: A Term to Capture Complexity
  • Proteomics and Microchemistry Core Facility, Memorial Sloan-Kettering Cancer Center
  • Biomolecular Mass Spectrometry Laboratory, École Polytechnique Fédérale de Lausanne
  • Sanibel 2013: Top Down Proteomics Meets in St. Pete's Beach, Florida
  • Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA
  • Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, Cittadella Universitaria di Monserrato, Italia
  • Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory
  • Synchrotron SOLEIL, French National Synchrotron Facility
  • University of Arizona

Deep and quantitative top-down proteomics in clinical and translational research

on Tuesday, 11 November 2014.

Summary: It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics

Read the entire article (for free soon!) at the publisher's website.

A trailblazer in top down proteomics.

on Sunday, 10 November 2013.

A trailblazer in top down proteomics.

Ljiljana Paša-Tolic, better known as Lili, is EMSL's mass spectroscopy capability lead. With a scientific focus in biology, she is particularly interested in the biological applications of mass spectroscopy technology.

Paša-Tolic's primary research area is proteomics – the study of proteins, particularly their structures and functions. Most proteomics research is from bottom up, which means the proteins are broken up and analyzed using liquid chromatography coupled withmass spectroscopy. Bottom up proteomics gives researchers a broad look at the proteins present in the sample, but does not identify the diversity of the protein forms, or proteoforms.

Read the entire article at Phys.org

Publish your Dataset (for free!) with the CTDP

on Tuesday, 15 July 2014.

Publish your Dataset (for free!) with the CTDP

As many of you know, earlier this year, we rolled out the ability to publish datasets with the Consortium for Top Down Proteomics (CTDP).  In a collaboration with the Indiana University "IU ScholarWorks" Repository, the CTDP is able to publish data for long-term storage.  If you are interested, please contact the CTDP Dataset Manager, This email address is being protected from spambots. You need JavaScript enabled to view it.

Once published, you will have a stable "Uniform Resource Identifier" to include with your journal publication and we will link to it from the Consortium's Datasets Page, http://topdownproteomics.org/data. An example of a published dataset can be found here: http://topdownproteomics.org/data/item/ultraviolet-photodissociation-for-characterization-of-whole-proteins-on-a-chromatographic-time-scale