Define the architecture and develop the infrastructure for the Human Proteoform Atlas

The goal of this Initiative is to build the Human Proteoform Atlas, the definitive set of unique proteoforms capturing the diversity of proteins resulting from combinations of genetic polymorphisms, RNA splice variants, and post-translational modifications. This proteoform-specific information is critical to understanding the mechanisms of disease and to accelerate the development of more precise diagnostics and potential therapeutic agents.

The Initiative will craft standardized representations, identifiers, and nomenclature to enable the facile sharing of data and information. The Atlas will be designed to interact with other important repositories and databases, and will benefit from broad community input that will be provided by the working groups in the Initiative.

The Initiative is being led by Hartmut Schlüter of the University Medical Center Hamburg-Eppendorf and by Neil Kelleher of  Northwestern University