The Consortium for Top-Down Proteomics announced the launch of the Human Proteoform Project, with the goal to elucidate the complete set of diverse proteoforms produced from the ~20,000 genes encoded in the human genome.  This large undertaking will proceed along two pathways, with the first being a cell-based approach where all proteoforms at a detectable level will be characterized and stored in the publicly available Human Proteoform Atlas. The second path is a gene-based approach for targeted proteoform discovery where reagents will be developed to enrich and then characterize specific proteoform families.