Prof. Nick Young – Quantitative Proteoform Biology Reveals Mechanisms of Transcription Regulation
Apr 22, 2021 11:00 AM Eastern Time (US and Canada)
Nuanced regulation of gene transcription is essential for higher eukaryotes. The development of methods for the precise quantitation of histone proteoforms have revealed that both dynamic and persistent regulation of transcription is achieved in part through single-molecule combinations of post-translational modification acting synergistically or antagonistically. Extension of these methods into in vivo models have revealed differential spatial distributions of proteoforms and changes that occur over lifespans.
Prof Young is Assistant Professor, Verna & Marrs McLean Department of Biochemistry & Molecular Biology; Assistant Professor, Department of Molecular and Cellular Biology; Member, Dan L. Duncan Comprehensive Cancer Center