Dr. Huilin Li presents  “Probing the Structural, Dynamic, and Functional Processes of Protein-Effector Binding Using Integrative Structural Mass Spectrometry”

Apr 21, 2022 11:00 AM in Eastern Time (US and Canada)

Protein function in living cells is precisely regulated by many factors, such as mutations, covalent modifications or noncovalent binding of effector molecules ranging from as small as a proton to as large as another macromolecule.   Using an integrative approach by combining native MS or native top-down MS, hydrogen deuterium exchange MS, and molecular dynamic simulations, I will demonstrate how tags, PTMs, drugs, or proteins modulate proteins’ structures, dynamics, and functions.