The Consortium has launched a new Initiative to develop guidelines for the use of online capillary electrophoresis in separating proteins and non-covalent protein complexes for top-down and native mass spectrometry. One of the greatest challenges in analyzing intact proteins and protein complexes is the efficient separation of mixtures into their constituents before analysis by MS. The high resolution provided by CE will be particularly valuable in separating various proteoforms and non-covalent protein complexes present in biological and biopharmaceutical samp