Higher Resolution Improves Top-Down Protein Identification on Orbitrap Mass Spec for Large Proteins

David Horn - Product Manager, Biosoftware

David Horn presents his scientific poster on the necessity for high mass resolution (more than 200,000) for confidence in identification of proteins above 40kDa using yeast enolase. The comparison between various resolution settings for both direct infusion and LC-MS/MS data are shown, using the Thermo Scientific Orbitrap mass spectrometer to improve confidence and sequence coverage for identification of larger proteins.