Mass spectromety imaging can map the molecular distribution of species directly from biological tissues.  Combining this with top-down MS provides for the molecular classification of the tissue and identification of protein biomarkers, potentially yielding considerable diagnostic and prognostic value.

Recent Publications

Delcourt V, Franck J, Leblanc E, Narducci F, Robin Y-M, et al. 2017. Combined Mass Spectrometry Imaging and Top-down Microproteomics Reveals Evidence of a Hidden Proteome in Ovarian Cancer. EBioMedicine. 21:55–64
Schey KL, Hachey AJ, Rose KL, Grey AC. 2016. MALDI imaging mass spectrometry of Pacific White Shrimp L. vannamei and identification of abdominal muscle proteins. Proteomics. 16(11–12):1767–74
Sarsby J, Martin NJ, Lalor PF, Bunch J, Cooper HJ. 2014. Top-Down and Bottom-Up Identification of Proteins by Liquid Extraction Surface Analysis Mass Spectrometry of Healthy and Diseased Human Liver Tissue. J. Am. Soc. Mass Spectrom. 25(11):1953–61
Ait-Belkacem R, Berenguer C, Villard C, Ouafik L, Figarella-Branger D, et al. 2014. MALDI imaging and in-source decay for top-down characterization of glioblastoma. Proteomics. 14(10):1290–1301
Maier SK, Hahne H, Gholami AM, Balluff B, Meding S, et al. 2013. Comprehensive identification of proteins from MALDI imaging. Mol. Cell Proteomics. 12(10):2901–10
Rauser S, Marquardt C, Balluff B, Deininger S-O, Albers C, et al. 2010. Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry. J. Proteome Res. 9(4):1854–63