New Technique Developed for Top Down Proteomics Quantitation

A "Tandem mass tag protein labeling for top-down identification and quantification." was recently published in Analytical Chemistry. The authors from the Christian-Albrechts-Universit├Ąt, Kiel, Germany state that "The liberated reporter ions delivered expected ratios over a wide dynamic range independent of the protein charge state. Furthermore, protein sequence tags generated either by low-energy HCD or ETD activation along with the intact protein mass information allow for confident identification of small proteins below 35 kDa."