Top-Down Proteomics Becomes Reality
In the May 20, 2013 issue of C&E News (Volume 91, Issue 20), Senior Editor, Celia Henry Arnaud profiles the field of Top Down Proteomics in a cover story titled: "Top Down Proteomics Becomes Reality."
In the mid-1990s, as the Human Genome Project was in full swing, scientists started thinking about the protein complement of the genome, and proteomics—the identification and characterization of all of an organism’s proteins—was born. Early proteomics methods used enzymes to digest proteins into pieces that could be easily analyzed by mass spectrometry. Those methods are now mature and routinely detect peptides from thousands of proteins in a single run.
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