Advancing Biology through Technology and Computation
Minneapolis Convention Center, Minneapolis, MN
The 61st ASMS Conference on Mass Spectrometry and Allied Topics will be held June 9-13, 2013 in Minneapolis, MN.
The conference program begins on Sunday, June 9 with tutorial lectures at 5:00 pm and the opening session and plenary lecture at 6:45 pm. A Welcome Reception in the poster/exhibit hall will follow. Monday through Thursday are full program days of concurrent oral sessions, poster sessions, and workshops. Poster sessions are scheduled 10:30 am to 2:30 pm to allow four hours of viewing. The program will conclude on Thursday, June 13 with a plenary lecture followed by a Closing Gala at the Convention Center (ticket required).
The Consortium for Top Down Proteomics will be meeting on Monday, June 10, 2013 at a workshop from 5:45pm - 7:00pm. Organizers will be Ying Ge from the University of Wisconsin and Nick Young from the National High Magnetic Field Laboratory. We will see you then!
For more information on the program and how to register, please see the ASMS website.
Top Down Oral Presentations
Characterization of Modified RNA by Top Down Mass Spectrometry
Fragmenting Intact Macromolecules and Protein Assemblies: Native ESI and Top-down MS for Protein Biophysics and Analysis
Top-down Mass Spectrometry Enabled Cardiac Proteomics for Understanding Heart Failure
Unequivocal Determination of Site-Specific Protein Disulfide Bond Reduction Potentials by Top-Down FT-ICR MS/MS
Detailed characterization of complex protein and RNA modification patterns by top-down mass spectrometry
Antibody characterization by top-down and middle-down electron transfer dissociation using a high-field Orbitrap FTMS
Comprehensive Top Down Proteomics of Human Cells: The Role of Mitochondria and Membrane Proteins in Cellular Senescence
An integrated top-down and bottom-up proteomic approach to characterize antibodies
In-depth Mass Spectrometry Characterization of Therapeutic Antibodies for Efficient Biosimilar Development
Mass Spectrometry Imaging with a LAESI hybrid iontrap FT-ICR mass spectrometer
An Online Top-down Mass Spectrometry Based Strategy Aimed at Complete De novo Sequencing of Monoclonal Antibodies
Micro-Scale Native Top-Down LCMS of Cysteine-Linked Antibody-Drug Conjugates
Applications of an in situ Microextraction Based Surface Sampling System to Microorganism Analysis
Ex Hall A
Intact Protein Characterization by 193 nm Ultraviolet Photodissociation in an Orbitrap Elite
The way to isotopic resolution of mega Dalton protein mass spectra for top-down proteomics
Quantifying Proteoforms using High-Throughput Top-Down Proteomics for Cell-Based Biomarker Discovery
Using Prior Knowledge to Improve Scoring in High-Throughput Top-Down Proteomics Experiments
Ex Hall A
Microscopy Guided Atmospheric Ionization In Situ Top-Down Protein Mass Spectrometry
Exploring Neisseria meningitidis Virulence with Top-Down Mass Spectrometry
Top-Down Proteomics Becomes Reality
In the May 20, 2013 issue of C&E News (Volume 91, Issue 20), Senior Editor, Celia Henry Arnaud profiles the field of Top Down Proteomics in a cover story titled: "Top Down Proteomics Becomes Reality."
In the mid-1990s, as the Human Genome Project was in full swing, scientists started thinking about the protein complement of the genome, and proteomics—the identification and characterization of all of an organism’s proteins—was born. Early proteomics methods used enzymes to digest proteins into pieces that could be easily analyzed by mass spectrometry. Those methods are now mature and routinely detect peptides from thousands of proteins in a single run.
Read the Full Article
Neil Kelleher and Lloyd Smith propose that the scientific community adopt the term ‘proteoform’ to refer to all the different forms that a protein can take. Will the community adopt it?
In the March 2013 issue of Nature Methods, Neil Kelleher and Lloyd Smith, investigators within the Consortium for Top Down Protoemics, have proposed a new term for the myriad forms of proteins that can be found in nature.
See the Methagora blog post by Allison Doerr: An all-encompassing term to describe protein complexity
Read the Article in Nature Methods: Proteoform: a single term describing protein complexity