Deep and quantitative top-down proteomics in clinical and translational research

on Tuesday, 11 November 2014.

Summary: It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics

Read the entire article (for free soon!) at the publisher's website.

A trailblazer in top down proteomics.

on Sunday, 10 November 2013.

A trailblazer in top down proteomics.

Ljiljana Paša-Tolic, better known as Lili, is EMSL's mass spectroscopy capability lead. With a scientific focus in biology, she is particularly interested in the biological applications of mass spectroscopy technology.

Paša-Tolic's primary research area is proteomics – the study of proteins, particularly their structures and functions. Most proteomics research is from bottom up, which means the proteins are broken up and analyzed using liquid chromatography coupled withmass spectroscopy. Bottom up proteomics gives researchers a broad look at the proteins present in the sample, but does not identify the diversity of the protein forms, or proteoforms.

Read the entire article at

Share your Research with the CTDP Community

on Tuesday, 14 October 2014.

Share your Research with the CTDP Community

We'd like to solicit your help in promoting your research.  If you'd like your top-down research promoted on the sliding images above, please create a slide for us and we'd be happy to feature it on the site.  

If you're comfortable making an image file, please follow the guidelines in the image shown here for general locations of information.  The final size of the image in the slideshow is 650 x 300 px, PNG image format preferred.  We often scale down 1730 x 800 px to ensure that there's enough resolution.  

If you'd prefer a powerpoint template, please see the file linked below (Note that the size of the template slide is 18" x 8.33" not the traditional PowerPoint size.  Once you're done, please send that image (or powerpoint file) to the Consortium's webmaster @ This email address is being protected from spambots. You need JavaScript enabled to view it. .  If the quality needs adjustment, we'll work with you.

62nd ASMS Conference on Mass Spectrometry and Allied Topics

on Saturday, 03 May 2014.

Baltimore Convention Center, Baltimore, MD

62nd ASMS Conference on Mass Spectrometry and Allied Topics

The 62nd ASMS Conference on Mass Spectrometry and Allied Topics will be held June 15-19, 2014 in Baltimore, MD. 

The conference program begins on Sunday, June 15 with tutorial lectures at 5:00 pm and the opening session and plenary lecture at 6:45 pm. A Welcome Reception in the poster/exhibit hall will follow. Monday through Thursday are full program days of concurrent oral sessions, poster sessions, and workshops. Poster sessions are scheduled 10:30 am to 2:30 pm to allow four hours of viewing. The program will conclude on Thursday, June 19 with a plenary lecture followed by a Closing Gala at the Convention Center (ticket required).

For more information on the program and how to register, please see the ASMS website.


 Top Down Oral Presentations (TBD)