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The Consortium for Top Down Proteomics Launches Pilot Project for Characterization of Monoclonal Antibodies

Twenty-five laboratory study to illustrate the capabilities of top-down mass spectrometry in detailing monoclonal antibody structure and modifications

CAMBRIDGE, MA--(Marketwired - February 28, 2017) - The Consortium for Top Down Proteomics today announced the launch of their inter-laboratory study for characterizing monoclonal antibodies (mAbs) by top-down mass spectrometry techniques. With the continuing growth in the development and adoption of mAbs for a wide range of therapeutic uses, there is increasing demand for higher quality characterization of these complex species.

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Deep and quantitative top-down proteomics in clinical and translational research

Help Me With My English Essay Book Editing Services Uk Summary: It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics

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A trailblazer in top down proteomics.

A trailblazer in top down proteomics.

Ljiljana Paša-Tolic, better known as Lili, is EMSL's mass spectroscopy capability lead. With a scientific focus in biology, she is particularly interested in the biological applications of mass spectroscopy technology.

Paša-Tolic's primary research area is proteomics – the study of proteins, particularly their structures and functions. Most proteomics research is from bottom up, which means the proteins are broken up and analyzed using liquid chromatography coupled withmass spectroscopy. Bottom up proteomics gives researchers a broad look at the proteins present in the sample, but does not identify the diversity of the protein forms, or proteoforms.

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Publish your Dataset (for free!) with the CTDP

Publish your Dataset (for free!) with the CTDP

As many of you know, earlier this year, we rolled out the ability to publish datasets with the Consortium for Top Down Proteomics (CTDP).  In a collaboration with the Indiana University "IU ScholarWorks" Repository, the CTDP is able to publish data for long-term storage.  If you are interested, please contact the CTDP Dataset Manager, This email address is being protected from spambots. You need JavaScript enabled to view it.

Once published, you will have a stable "Uniform Resource Identifier" to include with your journal publication and we will link to it from the Consortium's Datasets Page, http://topdownproteomics.org/data. An example of a published dataset can be found here: http://topdownproteomics.org/data/item/ultraviolet-photodissociation-for-characterization-of-whole-proteins-on-a-chromatographic-time-scale

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